Integration of whole genome sequencing and transcriptomics reveals a complex picture of the reestablishment of insecticide resistance in the major malaria vector Anopheles coluzzii전체 게놈 시퀀싱 및 전 사체의 통합은 주요 말라리아 벡터 Anopheles coluzzii에서 살충제 저항성의 재건에 대한 복잡한 그림을 보여줍니다.Research Article Published on 2021-12-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] alteration Anophele approach block change changes in colony complex complexity determine diagnostic Diagnostic markers elevated expression of gene Genetic genetic background Genome genomic genomic change increase in increased respiratory rate increasingly insecticide integration inversion Laboratory malaria malaria control malaria vector marker mechanism metabolism microbial Microbiome original oxidative phosphorylation pathway phenotype Population Pyrethroids respiratory rate reveal RNAseq Sequencing subject subset susceptible Transcriptome transcriptomic transcriptomics translated whole genome Whole genome sequencing [DOI] 10.1371/journal.pgen.1009970 PMC 바로가기 [Article Type] Research Article
Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus서아프리카 Anopheles의 pirimiphos-methyl에 대한 내성은 Ace1 유전자좌의 복제 및 유전자이입을 통해 확산되고 있습니다.Research Article Published on 2021-01-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] ACE1 acetylcholinesterase African Analysis analysis Anophele Anopheles gambiae approach association Carbamate Combination complex Control copy number diagnostic dominant driven by duplication duplications effective Effectiveness enzyme Genetic genomes genomic Haplotype highlight increasingly insecticidal insecticide insecticides Intervention locus malaria malaria vector molecular Mutation Non-synonymous occur organophosphate overcome phenotypic pirimiphos-methyl Population populations Predictive Predictive value predictor Prevent provide public health reduce Replication resistance resistance mechanism resistance mechanisms selection pressure sequenced specimen Spread sub-Saharan Africa Surveillance transferred Transmission unique Variation vector vectors West whole genome [DOI] 10.1371/journal.pgen.1009253 PMC 바로가기 [Article Type] Research Article
An Africa-wide genomic evolution of insecticide resistance in the malaria vector Anopheles funestus involves selective sweeps, copy number variations, gene conversion and transposons말라리아 매개체 Anopheles funestus의 살충제 저항성의 아프리카 전역 게놈 진화에는 선택적 스윕, 복제 수 변이, 유전자 전환 및 트랜스포존이 포함됩니다Research Article Published on 2020-06-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] alleles Analysis analysis Anophele approach bed net complex copy number cytochrome P450 driven by Effectiveness Evidence evidence of Evolution exhibited gene conversion gene flow Genes genetic diversity genomic genomic change genomic region glutathione greater haplotypes highlighting independent insecticide insecticides insertion Intervention Local loci locus malaria malaria control malaria vector management metabolic Metabolic resistance molecular molecular evolution Multiple performed Population pyrethroid respond risk selection pressure selective sweep selective sweeps signature Spread Temporal transposon Variation variations vector control whole genome [DOI] 10.1371/journal.pgen.1008822 PMC 바로가기 [Article Type] Research Article
Experimental population modification of the malaria vector mosquito, Anopheles stephensi말라리아 매개 모기인 Anopheles stephensi의 실험적 개체군 변형Research Article Published on 2019-12-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 1:1 accumulation Anophele anticipated approach Asian Author can be used Cas9 caused cleavage Effect Efficacy Efficiency effort evaluated exhibited exhibiting expected experimental design extinction favor feature female Genetic genetics Genome genomic IMPROVE in some insect Insects Kynurenine Laboratory malaria malaria vector male methodology Modification much lower Mutagenesis NHEJ nonhomologous open overlapping percentages Population populations prevented problem reached recent Release released repeated reproductive resulting Spread strain Strains survival target gene Target genes transgene Transmission Trial vector-borne diseases were used while [DOI] 10.1371/journal.pgen.1008440 PMC 바로가기 [Article Type] Research Article
Field-Caught Permethrin-Resistant Anopheles gambiae Overexpress CYP6P3, a P450 That Metabolises Pyrethroids현장에서 포착된 퍼메트린 내성 Anopheles gambiae CYP6P3, 피레스로이드를 대사하는 P450 과발현Research Article Published on 2008-11-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] A. gambiae adaptive adaptive mechanism adaptive mechanisms Alpha alpha-cyano Anopheles gambiae anopheline mosquitoes Author bioassays compounds Critical CYP6P3 cytochrome P450 detect disease spread Efficacy ENCODE enzyme Enzymes Evolution facilitate found Frequency Gene Gene Expression Genetic Health health problem identify individual insect insecticide insecticides Insects involved lead low frequencies malaria malaria vector malaria vector control mechanism Messenger RNA Metabolic resistance metabolise Molecular assay molecular mechanism molecular mechanisms MONITOR natural selection overexpressed P450 pesticide pesticides phenotyped populations public health pyrethroid Pyrethroids receiving recessive allele reducing resistance significantly sub-Saharan Africa Survivors sustainability trait transcript level translated Transmission undergo [DOI] 10.1371/journal.pgen.1000286 PMC 바로가기 [Article Type] Research Article